Predicting Drug Efficacy for Cognitive Deficits in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Predicting drug efficacy for cognitive deficits in schizophrenia.
The purpose of this article is to discuss the prediction of cognitive enhancement in schizophrenia from preclinical data. Despite increasing focus on the significance of cognitive impairment in schizophrenia, the progress of novel treatments has been slow. Hyman and Fenton's identification of a "translational gap" between preclinical and clinical science underscores the need to revise preclinic...
متن کاملSchizophrenia: Cognitive Deficits and Perceptual Deficits
Schizophrenia is a complex and severe mental disorder that affects about 1% of the population, clinically characterized by positive, negative, and disorganized symptoms. It is widely accepted that a combination of genetic and environmental factors lead to the onset of schizophrenia. The past two decades have witnessed the increasingly important role of cognitive deficits in schizophrenia, such ...
متن کاملLongitudinal course of cognitive deficits in schizophrenia.
Cognitive deficits are a core feature of schizophrenia, and patients with schizophrenia demonstrate deficits, early in the course of the illness, in most domains of cognitive functioning compared to healthy control subjects, suggesting a generalized cognitive impairment. 1,2 The neuropsychological profile of patients typically consists of deficits in speed of processing, attention/vigilance, wo...
متن کاملCognitive deficits and functional outcome in schizophrenia
Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe across several domains, including attention, working memory, verbal learning and memory, and executive functions. These deficits pre-date the onset of frank psychosis and are stable throughout the course of the illness in most patients. Over the past decade, the focus on these deficits has increased dramat...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2005
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbi058